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Combinase® AQ Nasal Spray, manufactured by Zydus Cadila and marketed by German Remedies, comprises two active ingredients called Fluticasone Propionate, topical corticosteroid, and Azelastine — a potent, second-generation, selective, histamine antagonist (histamine-H1-receptor antagonist).


- relief of symptoms of seasonal allergic rhinitis in patients 6 years of age and older.

MOA (mechanism of action):

Fluticasone Propionate inhibits multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in allergic and non-allergic-mediated inflammation. This contributes to the efficacy in the treatment of allergic rhinitis. Azelastine competes with histamine for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine and other mediators involved in the allergic response.


The recommended dosage is 1 spray in each nostril twice daily.

Administer by the intranasal route only.

Shake the bottle gently before each use.

Prime Combinase® AQ Nasal Spray before initial use by releasing 6 sprays or until a fine mist appears. When Combinase® AQ Nasal Spray has not been used for 14 or more days, reprime with 1 spray or until a fine mist appears.

Avoid getting Combinase® AQ Nasal Spray into the eyes. If sprayed in the eyes, flush eyes with water for at least 10 minutes.


Visual disorders may be reported with Combinase® AQ Nasal Spray use, which may include cataract, glaucoma.

When Combinase® AQ Nasal Spray is used at higher than recommended dosages or in susceptible individuals at recommended dosages, systemic corticosteroid effects such as hypercorticism and adrenal suppression may appear. If such changes occur, the dosage should be discontinued slowly.

Routine monitoring in children receiving Combinase® AQ Nasal Spray to check for any reduction in growth velocity should be considered.

Patients should be cautioned against engaging in hazardous occupations requiring complete mental alertness and motor coordination such as operating machinery or driving a motor vehicle after administration of Combinase® AQ Nasal Spray.

Corticosteroids may cause a reduction in growth velocity when used to pediatric patients. Monitor the growth routinely of pediatric patients receiving Combinase® AQ Nasal Spray.

Missing a dose

If you miss a dose you should spray it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not spray a double dose of Combinase® AQ Nasal Spray to compensate the missed dose.


If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children. Do not refrigerate or freeze. It is best to store your Combinase® AQ Nasal Spray upright. Always keep the cap on.

Side effects

The most common side effects associated with Combinase® AQ Nasal Spray are:

  • somnolence
  • local nasal effects (epistaxis, nasal ulceration, nasal septal perforation, impaired wound healing)
  • glaucoma and cataracts
  • immunosuppression
  • hypothalamic-pituitary-adrenal (HPA) axis effects (growth reduction)

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.


Do not use Combinase® AQ Nasal Spray if you are allergic to Fluticasone Propionate, Azelastine or any ingredients comprised in the medication.

Do not use Combinase® AQ Nasal Spray if you have intraocular pressure, glaucoma and/or cataracts, infection in the nasal passages or sinuses (the infection should be treated), recent nasal surgery or injury (only use when the nose has healed), tuberculosis.

Do not combine Combinase® AQ Nasal Spray with other drugs that contain corticosteroids (steroid tablets or injected steroids, steroid creams), drugs for asthma, ritonavir or cobicistat (for HIV), telaprevir (for hepatitis C) ketoconazole (for fungal infections), antihistamines, decongestant nasal sprays.

Do not use Combinase® AQ Nasal Spray if you are pregnant, plan to have a baby or are breastfeeding. Consult with the doctor.

Q: What is Combinase® AQ Nasal Spray used for?

A: Combinase® AQ Nasal Spray is used to prevent and treat seasonal allergic rhinitis in adults and children aged 6 years and older. The spray relives nasal congestion, runny nose, sneezing and itching due to hayfever, house dust mites.

Q: Is Combinase® AQ Nasal Spray safe?

A: Yes. Combinase® AQ Nasal Spray is safe if used as directed by your physician.

Q: How many sprays should I use daily?

A: The usual adult dose is 2 sprays into each nostril once a day, at the same time of day. The dose for kids is 1 spray in each nostril once a day, at the same time of day.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 15.00 per order
EMS  Trackable, where available 5-9 business days USD 25.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 15.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 25.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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