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Frumil®

Frumil® is a diuretic medication that decreases the amount of water in the body promoting urination. Frumil® tablets are used to treat hypertension (elevated blood pressure) and edema. Suitable for patients over 18 years of age.

Other names for this medication:
Amifru, Amimide, Exna-K, Lasiride, Donafruse, Co-Amilofruse

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Active Ingredient:
Furosemide, Amiloride

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Description

Frumil® is manufactured by Geno Pharmaceutical. The active substances of these tablets are Furosemide, a sulfonamide-type loop diuretic, and Amiloride, an antihypertensive, potassium-sparing diuretic.

Indications:

- peripheral edema or edema associated with heart failure, chronic renal failure (renal impairment) or nephrotic syndrome;

- management of hypertension (elevated blood pressure).

Frumil® also can be used as an alternative oral agent for management of nephrogenic diabetes insipidus (do not confuse with diabetes mellitus or sugar diabetes), followed by abnormal production of urine (polyuria) and constant thirst (polydipsia).

MOA (mechanism of action):

Furosemide inhibits water reabsorption in the nephron (basic kidney unit) by blocking the absorption of sodium, chloride and excessive liquid from the kidney tubules, thereby increasing urine formation (diuresis). With increased urination, Furosemide makes unnecessary water leave the body, therefore reduces the volume of blood in vessels and lowering blood pressure.

Amiloride binds to certain sodium channels and inhibits sodium reabsorption in the tubules and collecting ducts in the kidneys. This promotes the loss of sodium and water leading to the reduction of plasma and extracellular fluid volume. With the decrease of the aforementioned substances, peripheral resistance got reduced as well, which leads to lower blood pressure.

Dosage

Frumil® tablets should be swallowed whole and taken on an empty stomach with some water.

The exact dosage, as well as the course duration, must be determined by a doctor for each individual patient.

Frumil® tablets are only for oral use.

Do not take Frumil® later than 12 noon, as the diuretic action of this medicine may disturb your sleep.

Do not give Frumil® to patients under 18 years of age.

Potassium blood level should be monitored carefully during the Frumil® treatment course.

Edema and hypertension:

The average recommended dose is 1-2 tablets (40-80 mg/5-10 mg) daily, preferably in the morning.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 20 and 25 degrees C and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with the use of Frumil® are:

  • dry mouth
  • unusual thirst
  • muscle pain
  • dizziness
  • fever
  • nausea and vomiting
  • loss of appetite
  • diarrhoea
  • ringing or buzzing in the ears
  • irregular or fast heart beat
  • painful urination
  • tiredness and fatigue
  • nose bleeds
  • allergic reactions (rash, hives, itching, raised welts, facial swelling, fever, difficulty breathing, peeling or blistering skin)
  • dehydration

Side effects occurrence does not only depend on the medication you are using, but also on your overall health and other factors.

Contraindications

Do not take Frumil® if you are allergic to Furosemide or Amiloride.

Do not take Frumil® if you are allergic to any other ingredient comprised in Frumil®.

Do not take Frumil® if you have a history of severe allergic reaction associated with the use of sulfonamides or sulfonylureas.

Do not combine Frumil® with the use of antidiuretics.

Do not take Frumil® if you have Addison’s disease, hypovolemia, hypokalemia, hyperkalemia, severe hyponatraemia, anuria, liver of kidney problems, hepatic coma or precoma, low sodium or potassium levels in your blood, dehydration, diabetes mellitus, gout or prostate problems.

Do not combine Frumil® with the use of potassium supplements, stool softeners (laxatives), other diuretics (triamterene, bendroflumethiazide), ACE inhibitors (ramipril, enalapril, perindopril), angiotensin II receptor antagonists (losartan, candesartan, irbesartan), heart medications (digoxin, dofetilide), antipsychotics (lithium), muscle relaxants (diazepam, lorazepam, clonazepam), respiratory diseases drugs (theophylline), epilepsy drugs (phenytoin, carbamazepine), certain cancers medications (cisplatin, aminoglutethimide, methotrexate), anti-inflammatory drugs for pain or swelling (aspirin, ibuprofen, ketoprofen, indometacin), immunosuppresives (ciclosporin, tacrolimus), ulcer medications (carbenoxolone), antidepressants (reboxetine), antifungals (amphotericin), corticosteroids (prednisolone), gout drugs (probenecid), liquorice, certain antibiotics (gentamicin, amikacin, neomycin, netilmicin, tobramycin, vancomycin, cephalosporins), asthma medications (salbutamol, terbutaline sulphate, salmeterol, formoterol or bambuterol).

Do not take Frumil® if you are on salt-restricted or potassium-rich diet.

Do not take Frumil® if you are pregnant, intend to get pregnant or breastfeeding.

Do not take Frumil® if you are under 18 years of age.

Q: What is Frumil® used for?

A: Frumil® is a diuretic medication that decreases the amount of water in the body promoting urination. Frumil® tablets are used to treat hypertension (elevated blood pressure) and edema.

Q: Is Frumil® safe?

A: Frumil® tablets are safe as long used by adult patients for prescribed condition and at prescribed doses.

Q: Can Frumil® be used in pregnant women?

A: No. Do not take Frumil® if you are pregnant, intend to get pregnant or breastfeeding.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide Shipping

Worldwide Shipping

Registered Mail  Not trackable 14-21 business days USD 20.00 per order
EMS  Trackable, where available 5-9 business days USD 30.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 20.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 30.00, signature is required on delivery.
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