Description
Ciplox® solution is manufactured by Cipla. The active ingredient of the medication is Ciprofloxacin, the second-generation, synthetic antibiotic from the Fluoroquinolones class.
Indications:
- bacterial eye infections (corneal ulcers, bacterial conjunctivitis, superficial infections of the eyes);
- bacterial ear infections (otitis externa, acute otitis media, chronic suppurative otitis media, and prophylaxis in otic surgeries such as mastoid surgery).
Do not use Ciplox® eye and ear drops to treat a viral or fungal infection in the eye or ear.
MOA (mechanism of action):
Ciprofloxacin is a bactericidal antibiotic with a broad-spectrum activity. Ciprofloxacin inhibits two enzymes – topoisomerase II (DNA gyrase) and topoisomerase IV, necessary for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination. This inhibition prevents cell division and leads to bacteria death. Ciprofloxacin shows high efficacy against Pseudomonas aeruginos, Serratia marcescens, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus (Viridans group), Haemophilus influenzae, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae.
Dosage
For corneal ulcers:
Day 1: two drops into the treated eye every 15 minutes for the first 6 hours and then two drops into the affected eye every 30 minutes for the remainder of day.
Day 2: two drops into the treated eye hourly.
Day 3 – Day 14: two drops into the treated eye every 4 hours.
Treatment course may be continued after 14 days if corneal re-epithelialization has not occurred.
For bacterial conjunctivitis:
1-2 drops into the conjunctival sac(s) every 2 hours while being awake for 2 days;
1-2 drops every 4 hours while being awake for the next 5 days.
For superficial eye infection:
1-2 drops into the treated eye while being awake 4 times a day. In severe infection, the dose may be doubled. The recommended duration of therapy is 21 days.
For ear infections:
Start with 2-3 drops every 2-3 hours, reduce the frequency of the dropping with control of infection. The recommended duration of therapy is 7 days.
Precautions
Ciplox® eye and ear drops are not intended for use in children under 1 year of age.
Ciplox® is a sterile solution for topical ophthalmic and otic use only.
Ciplox® solution is not for injection.
Ciplox® solution is associated with allergic reactions, even following a single dose. Discontinue using Ciplox® immediately and contact your physician at the first sign of a rash or allergic reaction.
Avoid contaminating the applicator tip with eye, fingers or another source.
Remove contact lenses before using Ciplox® drops for eye infection.
Patients should not wear contact lenses while using Ciplox® drops for eye infection.
Wash your hands before using the eye drops.
Missing a dose
If you miss a dose you should instill it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not instill a double dose to make up for a missed one.
Overdose
If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.
Storage
Store at cool room temperature, away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use. Use within one month after opening a container. Keep out of the reach of children.
